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Scientific Papers

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  • An Australian study to evaluate the impact of a structured bowel management program (SBMP) in an inpatient rehabilitation service, using NutriKane™ D.
  1. Amatya, B., et al., Evaluation of the structured bowel management program in inpatient rehabilitation: a prospective study. Disabil Rehabil, 2015: p. 1-8. Evaluation of the structured bowel management program in inpatient rehabilitation: a prospective study - PubMed (nih.gov)

 

  • An Australian study with 54 participants with spina bifida to assess the effectiveness of an interdisciplinary ambulatory programme, using NutriKane™ D.
  1. Khan, F., et al., Rehabilitation outcomes in persons with spina bifida: A randomised controlled trial. J Rehabil Med, 2015. Rehabilitation outcomes in persons with spina bifida: a randomised controlled trial — Monash University

 

  • An Australian study of 51 adult diabetic participants living with diabetes, that were assessed in both a rehabilitation setting, and after release to determine the effectiveness of NutriKane D™ in improving blood sugar level control and bowel dysfunction.
  1. Amatya, B., Lee, S.Y., Elmalik, A., Lowe, M., Khan, F., Efficacy of Dietary Sugarcane Product on Bowel Function and Blood Sugar Level in Adult Diabetic Patients: A Randomised Controlled Trial. 2018. 5-2018. Efficacy of Dietary Sugarcane Product on Bowel Function and Blood Sugar Level in Adult Diabetic Patients: A Randomised Controlled Trial | Request PDF (researchgate.net)

 

  • An Australian pilot study to investigate the effectiveness of a prebiotic sugarcane flour in alleviating symptoms in 43 medically-diagnosed gastroesophageal reflux disease (GERD) patients. The study was a single centre, double-blinded, placebo-controlled randomized trial.
  1. Beckett, J.M., et al., Anti-Heartburn Effects of Sugar Cane Flour: A Double-Blind, Randomized, Placebo[1]Controlled Study. Nutrients, 2020. 12(6). Anti-Heartburn Effects of Sugar Cane Flour: A Double-Blind, Randomized, Placebo-Controlled Study - PubMed (nih.gov)

 

  • A 12-week study to compare the effects of two different types of dietary fibre ( sugar cane residue and wheat bran ) on faecal steroid and lipid excretion.
  1. Walters, R.L., et al., Effects of two types of dietary fibre on faecal steroid and lipid excretion. Br Med J, 1975. 2(5970): p. 536-8. Effects of two types of dietary fibre on faecal steroid and lipid excretion. - PMC (nih.gov)

 

  • A study of 10 healthy, non-smoking, normal weight young adults to determine whether a bioflavonoid extracted from sugar cane, could effectively reduce the postprandial glycaemic response to a high-GI meal (wheat biscuits with milk).
  1. Holt, S., et al., A bioflavonoid in sugar cane can reduce the postprandial glycaemic response to a high-GI starchy food. Vol. 12 Suppl. 2003. S66. [PDF] A bioflavonoid in sugar cane can reduce the postprandial glycaemic response to a high-GI starchy food. | Semantic Scholar

 

  • A 30-day trial with a 6 month follow up, to evaluate the efficacy and safety of sugarcane bagasse dietary fibre as an adjuvant therapy for improving quality of life in patients with stable chronic obstructive pulmonary disease (COPD).
  1. Miao, L., Sugarcane bagasse dietary fiber as an adjuvant therapy for stable chronic obstructive pulmonary disease: a four-center, randomized, double-blind, placebo-controlled study. (Abstracts: The Journal of Traditional Chinese Medicine). The Journal of Chinese medicine, 2016(112):p.72. Sugarcane bagasse dietary fiber as an adjuvant therapy for stable chronic obstructive pulmonary disease: a four-center, randomized, double-blind, placebo-controlled study - PubMed (nih.gov)

 

  • A study of 15 prediabetic men to investigate the effects of sorghum starch on postprandial blood glucose and insulin levels when consuming baked goods.
  1. Gu, X., Effects of Grain Sorghum Muffin on Blood Glucose and Insulin Responses in Prediabetic Men. 2014, ProQuest Dissertations Publishing. Effects of Grain Sorghum Muffin on Blood Glucose and Insulin Responses in Prediabetic Men | Semantic Scholar

 

  • A study to measure the contents of functional starch fractions, SDS (slowly-digestible starch) and RS (resistant starch), and to investigate the effects of grain sorghum on postprandial plasma glucose and insulin levels in 10 healthy men.
  1. Poquette, N.M., Gu, X., and Lee S.O., Grain sorghum muffin reduces glucose and insulin responses in men. Food Funct, 2014. 5(5): p. 894-9. [PDF] Grain sorghum muffin reduces glucose and insulin responses in men. | Semantic Scholar

 

  • A study to evaluate the GI and GL of different sorghum foods and compare them with those of equivalent wheat/rice-based foods.
  1. Prasad, M.P., et al., Glycaemic index and glycaemic load of sorghum products. J Sci Food Agric, 2015. 95(8): p. 1626-30. Glycaemic index and glycaemic load of sorghum products - PubMed (nih.gov)

 

  • A randomized, cross-over trial with 40 healthy subjects, using whole grain sorghum flaked biscuits to investigate mechanisms related to satiety.
  1. Stefoska-Needham, A., et al., Flaked sorghum biscuits increase postprandial GLP-1 and GIP levels and extend subjective satiety in healthy subjects. Mol Nutr Food Res, 2016. 60(5): p. 1118-28. Flaked sorghum biscuits increase postprandial GLP-1 and GIP levels and extend subjective satiety in healthy subjects - PubMed (nih.gov)

 

  • A systematic review of 19 studies between 1985 and 2015 to evaluate the health effects associated with the consumption of sorghum among humans.
  1. Simnadis, T.G., Tapsell, L.C. and Beck, E. J., Effect of sorghum consumption on health outcomes: a systematic review. Nutr Rev, 2016. 74(11): p. 690-707. Effect of sorghum consumption on health outcomes: a systematic review - PubMed (nih.gov)

 

  • A thesis comparing 3 different dietary fibres to examine their effect of chemical composition on physiological activity.
  1. Chong, R.W.W., Investigating the influence of dietary fibre on intestinal health, in Molecular sciences. 2019, Macquarie University. p. 258. Investigating the influence of dietary fibre on intestinal health (mq.edu.au)

 

  • A review on dietary fibres, that interact directly with gut microbes and lead to the production of key metabolites such as short-chain fatty acids, and a discussion on how dietary fibre impacts gut microbial ecology, host physiology, and health.
  1. Hewawasam Gamage, H.K.A., Investigating the impact of dietary fibre on the gut microbiota. 2017, Macquarie University: Sydney, Australia. The Impact of Dietary Fiber on Gut Microbiota in Host Health and Disease - PubMed (nih.gov)

 

  • A mouse trial assessing the effectiveness of a synbiotic approach of using prebiotics and probiotics to mitigate inflammation in induced colitis.
  1. Shinde, T., et al., Synbiotic Supplementation Containing Whole Plant Sugar Cane Fibre and Probiotic Spores Potentiates Protective Synergistic Effects in Mouse Model of IBD. Nutrients, 2019. 11(4). Synbiotic Supplementation Containing Whole Plant Sugar Cane Fibre and Probiotic Spores Potentiates Protective Synergistic Effects in Mouse Model of IBD - PubMed (nih.gov)

 

  • A mouse trial with a probiotic and prebiotic food ingredient combination to test for synergistic functioning in modulating the colonic microbiome and remediation the the gastrointestinal immune and inflammatory responses in a spontaneous colitic mouse model.
  1. Shinde, T., et al., Modulating the Microbiome and Immune Responses Using Whole Plant Fibre in Synbiotic Combination with Fibre-Digesting Probiotic Attenuates Chronic Colonic Inflammation in Spontaneous Colitic Mice Model of IBD. Nutrients, 2020. 12(8). Modulating the Microbiome and Immune Responses Using Whole Plant Fibre in Synbiotic Combination with Fibre-Digesting Probiotic Attenuates Chronic Colonic Inflammation in Spontaneous Colitic Mice Model of IBD - PMC (nih.gov)

 

  • A study using 32 cats over a 42-day period to evaluate the potential benefits of sugarcane fibre in preventing the formation of hairballs. Two insoluble fibre sources ( sugarcane fibre and cellulose ) were added to kibble diets.
  1. Loureiro, B.A., et al., Sugarcane fibre may prevent hairball formation in cats.

J Nutr Sci, 2014. 3: p. e20. Sugarcane fibre may prevents hairball formation in cats - PubMed (nih.gov)

 

  • A 20-day diet adaption trial of 24 healthy cats to explore the different potential benefits of divergent fibre ingredients on energy and macronutrient digestibility, fermentation product formation, postprandial metabolite responses, and colon histology of overweight cats.
  1. Fischer, M.M., et al., Fiber fermentability effects on energy and macronutrient digestibility, fecal traits, postprandial metabolite responses, and colon histology of overweight cats. J Anim Sci, 2012. 90(7): p. 2233-45. Fiber fermentability effects on energy and macronutrient digestibility, fecal traits, postprandial metabolite responses, and colon histology of overweight cats - PubMed (nih.gov)

 

  • A trial using two different approaches to test the performance of sugar cane fibre as a regulatory tool for cats to voluntarily reduce food intake.
  1. Rogues, J., et al., Reduction of cat voluntary feed intake in the short-term response to the sugar cane fibre supplementation. Journal of Applied Animal Nutrition, 2020. 8: p. 1-12. (PDF) Reduction of cat voluntary feed intake in the short-term response to the sugar cane fibre supplementation (researchgate.net)

 

  • The study evaluated the effects of using sorghum compared to easily digestible starch on the glycaemic control in 10 dogs with diabetes mellitus.
  1. Teshima, E., et al., Influence of type of starch and feeding management on glycaemic control in diabetic dogs. J Anim Physiol Anim Nutr (Berl), 2021. Influence of type of starch and feeding management on glycaemic control in diabetic dogs - PubMed (nih.gov)

 

  • 12 weeks trial on mice to compare the effects of three different dietary fibres (cellulose, psyllium and sugarcane ) on hepatic cellular signalling.
  1. Wang, Z.Q., et al., Comparing the effects of nano-sized sugarcane fiber with cellulose and psyllium on hepatic cellular signaling in mice. Int J Nanomedicine, 2012. 7: p. 2999-3012. Comparing the effects of nano-sized sugarcane fiber with cellulose and psyllium on hepatic cellular signaling in mice - PubMed (nih.gov)

 

  • 12 weeks trial, using 36 male mice, comparing the metabolic effects of 3 types of dietary fibres -- sugarcane fibre (SCF), psyllium (PSY), and cellulose (CEL) -- on body weight, carbohydrate metabolism, and stomach ghrelin gene expression in a high-fat diet.
  1. Wang, Z.Q., et al., Effects of Dietary Fibers on Weight Gain, Carbohydrate Metabolism and Gastric Ghrelin Gene Expression in High Fat Diet Fed Mice. Metabolism, clinical and experimental, 2007. 56(12): p. 1635-1642. Effects of dietary fibers on weight gain, carbohydrate metabolism, and gastric ghrelin gene expression in mice fed a high-fat diet - PubMed (nih.gov)

 

  • A trial involving 16 male rats that ran for 28 days to study sterol metabolism. The rats were fed either a semi-synthetic fibre-free diet or a diet containing cellulose (200 or 100 g/kg) or sugar-cane fibre (bagasse) at the same levels.
  1. Morgan, B., et al., Dietary fibre and sterol metabolism in the rat. British journal of nutrition, 2007. 32(2): p. 447-455. Dietary fibre and sterol metabolism in the rat | British Journal of Nutrition | Cambridge Core

 

  • An animal trial using female Sprague-Dawley rats to establish a menopausal model by oral administration of formestane and to compare the protective effect of resistant starch on lipid metabolism, with or without soybean feed.
  1. Ge, Y.F., et al., The resistant starch from sorghum regulates lipid metabolism in menopausal rats via equol. J Food Biochem, 2020. 44(8): p. e13295. The resistant starch from sorghum regulates lipid metabolism in menopausal rats via equol - PubMed (nih.gov)

 

  • An animal trial using male hamsters which ran for 4 weeks, to observe the effects of feeding grain sorghum lipid extract on cholesterol levels.
  1. Carr, T.P., et al., Grain sorghum lipid extract reduces cholesterol absorption and plasma non-HDL cholesterol concentration in hamsters. J Nutr, 2005. 135(9): p. 2236-40. Grain sorghum lipid extract reduces cholesterol absorption and plasma non-HDL cholesterol concentration in hamsters - PubMed (nih.gov)

 

  • An animal study using dogs to compare the fermentation characteristics and kinetic patterns of 10 carbohydrate sources.
  1. Calabrò, S., et al., Fermentation Characteristics of Several Carbohydrate Sources for Dog Diets Using the In Vitro Gas Production Technique. Italian Journal of Animal Science, 2013. 12(1): p. e4-e4. Fermentation Characteristics of Several Carbohydrate Sources for Dog Diets Using the In Vitro Gas Production Technique | Semantic Scholar

 

  • An in vitro colon cancer model that explored the anti-inflammatory properties of extracts of whole dried sugarcane.
  1. Bucio-Noble, D., et al., Polyphenol extracts from dried sugarcane inhibit inflammatory mediators in an in vitro colon cancer model. J Proteomics, 2018. 177: p. 1-10. Polyphenol extracts from dried sugarcane inhibit inflammatory mediators in an in vitro colon cancer model - PubMed (nih.gov)

 

  • An in vitro human digestive and gut microbiota model system to investigate the effect of three commercial fibre products; NutriKane™, Benefiber® and Psyllium husk (Macro) on the adult gut microbiota.
  1. Gamage, H., et al., Fiber Supplements Derived From Sugarcane Stem, Wheat Dextrin and Psyllium Husk Have Different In Vitro Effects on the Human Gut Microbiota. Front Microbiol, 2018. 9: p. 1618. Fiber Supplements Derived From Sugarcane Stem, Wheat Dextrin and Psyllium Husk Have Different In Vitro Effects on the Human Gut Microbiota - PubMed (nih.gov)

 

  • A study to evaluate the impact of sorghum bran polyphenols on gut microbiota and modulation of short-chain fatty acids (SCFA).
  1. Ashley, D., et al., Impact of Grain Sorghum Polyphenols on Microbiota of Normal Weight and Overweight/Obese Subjects during In Vitro Fecal Fermentation. Nutrients, 2019. 11(2): p. 217. Impact of Grain Sorghum Polyphenols on Microbiota of Normal Weight and Overweight/Obese Subjects during In Vitro Fecal Fermentation - PubMed (nih.gov)

 

  • Network pharmacology was used to identify key compounds and mechanism(s), in sorghum bicolor (SB ), against Type 2 Diabetes Mellitus.
  1. Oh, K.K., M. Adnan, and D.H. Cho, Network pharmacology of bioactives from Sorghum bicolor with targets related to diabetes mellitus. PLoS One, 2020. 15(12): p. e0240873. Network pharmacology of bioactives from Sorghum bicolor with targets related to diabetes mellitus - PubMed (nih.gov)

 

  • An in vitro model of inflammatory pathways to investigate whether the different flavonoids in sorghum and cowpea could synergistically reduce inflammation.
  1. Agah, S., et al., Complementary cereals and legumes for health: Synergistic interaction of sorghum flavones and cowpea flavonols against LPS-induced inflammation in colonic myofibroblasts. Mol Nutr Food Res, 2017. 61(7). Complementary cereals and legumes for health: Synergistic interaction of sorghum flavones and cowpea flavonols against LPS-induced inflammation in colonic myofibroblasts - PubMed (nih.gov)

 

  • This study examined the effect of ethanol extracts of several varieties of sorghum (S. bicolor) bran on albumin glycation, a non-enzymatic process thought to be important in the pathogenesis of many diabetic complications.
  1. Farrar, J.L., et al., A novel nutraceutical property of select sorghum (Sorghum bicolor) brans: inhibition of protein glycation. Phytother Res, 2008. 22(8): p. 1052-6. A novel nutraceutical property of select sorghum (Sorghum bicolor) brans: inhibition of protein glycation - PubMed (nih.gov)

 

  • Collectively, in vitro, ex vivo and in silico data revealed that sugarcane sucrase inhibitor (sucinh) is selective for intestinal sucrase. A new horizon towards polypeptides derived from food sources emerge as a promising strategy for dietary interventions for prediabetic conditions.
  1. Abduldileep, S., et al., A bioactive polypeptide from sugarcane selectively inhibits intestinal sucrase. International journal of biological macromolecules, 2020. 156: p. 938-948. A bioactive polypeptide from sugarcane selectively inhibits intestinal sucrase - PubMed (nih.gov)

 

  • This study evaluated the antioxidant activity of a polyphenol-rich sugarcane extract and its therapeutic potential to regulate carbohydrate metabolism and protect against metabolic disorders such as type 2 diabetes.
  1. Ji, J., et al., Antioxidant and Anti-Diabetic Functions of a Polyphenol-Rich Sugarcane Extract. Journal of the American College of Nutrition, 2019: p. 1-11 Antioxidant and Anti-Diabetic Functions of a Polyphenol-Rich Sugarcane Extract - PubMed (nih.gov)